OIL-GAS.1
نویسندگان
چکیده
منابع مشابه
Hedgehog signaling: cooking with Gas1.
The mechanisms by which morphogens, such as Sonic hedgehog (Shh), specify distinct cell fates in a concentration-dependent manner are not fully understood. Shh signaling is regulated by a feedback network that comprises Shh-binding factors, the expression of which is controlled by the Hedgehog pathway itself. Recent studies have identified the hedgehog-binding protein growth arrest-specific gen...
متن کاملEmbryonic expression patterns of the mouse and chick Gas1 genes
Control of cell proliferation is essential to generate the defined form of a multi-cellular organism. While much is known about the regulators for cell cycle progression, relatively little is known about the state of growth arrest. Growth arrest (G0) is defined as a cell in a metabolically active but proliferation-quiescent state (reviewed in Baserga (1985) The Biology of Cell Reproduction), ty...
متن کاملBoc modifies the spectrum of holoprosencephaly in the absence of Gas1 function
Holoprosencephaly is a heterogeneous developmental malformation of the central nervous system characterized by impaired forebrain cleavage, midline facial anomalies and wide phenotypic variation. Indeed, microforms represent the mildest manifestation, associated with facial anomalies but an intact central nervous system. In many cases, perturbations in sonic hedgehog signaling are responsible f...
متن کاملGenetic interactions between the hedgehog co-receptors Gas1 and Boc regulate cell proliferation during murine palatogenesis
Abnormal regulation of Sonic hedgehog (Shh) signaling has been described in a variety of human cancers and developmental anomalies, which highlights the essential role of this signaling molecule in cell cycle regulation and embryonic development. Gas1 and Boc are membrane co-receptors for Shh, which demonstrate overlapping domains of expression in the early face. This study aims to investigate ...
متن کاملFueling Low-level Agn Activity through the Stochastic Accretion of Cold Gas1
Using a simple description of feedback from black hole growth, we develop an analytic model for the fueling of Seyferts (low-luminosity AGN) and their relation to their host galaxies, Eddington ratio distributions, and cosmological evolution. We derive a solution for the time evolution of accretion rates in a feedback-driven blast wave, applicable to large-scale outflows from bright quasars in ...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 1894
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja02108a008